无色素性恶性黑色素瘤28例诊断及治疗分析

Diagnosis and treatment of 28 cases with amelanotic malignant melanoma

目的 分析无色素性恶性黑色素瘤的诊断及治疗的结果。方法 1986年 3月至 2 0 0 0年 10月 ,我们收治了 2 8例无色素性恶性黑色素瘤患者 ,全部经免疫组化确定。结果 1年生存率 71% ,2年生存率 39% ,3年生存率2 5 % ,5年生存率 7% ,最长生存 6年。结论 无色素性恶性黑色素瘤 ,很容易误诊为其它恶性肿瘤 ,需做免疫组化才能确诊 ,合理的将手术、化疗、单次大剂量放疗及免疫治疗结合起来 ,是目前治疗恶性黑色素瘤的主要方法。

Objective To evaluate the effect of diagnosis and treatment for amelanotic malignant melanoma.Methods Twenty eight patients with amelanotic malignant melanoma confirmed by immunochemistry were treated from from March,1986 to Oct. 2000.Results The 1 ,2 ,3 ,5 year survival rates were 71%,39%,25%,7% respectively and the longest survival time was 6 years.Conclusion Combined therapy of surgery,chemotherapy,radiotherapy in fractional high dose and immunotherapy is an effective approach in treating amelanotic malignant melanoma.