脑缺血再灌流后HSP70蛋白的表达及其与凋亡的关系

The Relation of HSP70 protein Expression and apoptosis in rat brain following cerbral ischemia-reperfusion.

目的 :研究脑缺血再灌流后 HSP70蛋白的表达及其与凋亡的关系。方法 :应用免疫组化的方法观察大鼠局灶性脑缺血再灌流后脑组织 HSP70蛋白的表达和细胞凋亡的分布。结果 :缺血 2 h再灌流 0 h即可见 HSP70表达和凋亡细胞 ,HSP70至 2 4h达高峰 ,凋亡细胞数于再灌流后 2 4～ 48h达高峰。结论 :脑缺血诱导 HSP70蛋白的表达和细胞凋亡 ,脑缺血后

To study the cel apoptosis and the expression of HSP70 in rat brain following cerbral ischemia^reperfusion. Methods: HSP70 protein expresion was examined vial immunohistochemistry, at 0~72h reperfusion after the Middle cerebral artery (MCA) was occluded for 2h in rats. Simutaneously, the distribution of apoptosis was observed. Results: The expression of HSP70 reached peak at 24h, and cell apotosis reached peak at 24~48h.. Conclusion: Cerebral ischemia reperfusion can induce HSP70 protein expression and apoptosis of cells. HSP70 can suppress apoptosis.