重力变化对表皮生长因子诱导的信号转导的影响

Influence of Gravity Change on EGF-induced Signal Transduction.

随着航空航天技术的进一步发展 ,重力的变化导致人体各种生理效应就越来越引起人们的重视 ,尤其是重力变化对细胞因子信号转导的影响近年来研究较多。表皮生长因子 (EGF)诱导的信号转导会对多种细胞产生增殖效应 ,因此一直是多年来的研究热点。其早期的细胞生物学变化包括 :受体募集、细胞球形化和早期的基因表达。经过对EGF诱导人类A431细胞系的研究发现 :在微重力条件下EGF诱导的c fos和c jun的基因表达降低 ,而这一结果是由于EGF受体和蛋白激酶C介导的信号转导通路的变化引起的。同时发现细胞骨架的主要成分肌动蛋白微丝系统也和这种信号转导途径有关 。

With the development of aerospace technology, biological effects induced by alteration of gravitation are drawing more and more attention. Among them the influence of alteration of gravitation on cytokine induced signal transduction has been well studied recently. Epidermal growth factor (EGF) induced signal transduction can activate increase of cell proliferation in most cell types, so it is always a hotspot in these years. Among the early effects evoked by EGF are receptor clustering, cell rounding, and early gene expression. After the study about the induction of EGF on human A431 cell line, it was observed that EGF induced c fos and c jun expression decreased in microgravity. This was caused by alteration of the EGF receptor and protein kinase C mediated signal transduction pathways. Meanwhile the key component of cytoskeleton, the actin microfilament system, was found to be linked to the EGF induced signal transduction cascades either. So it seems reasonable to suggest that the cytoskeleton constitutes the gravity sensitive cell component.