+Gz作用下心脏结构与功能异常及其机理研究进展

The Progress on +Gz Stress-induced Injuries of the Cardiac Structure and Function and Their Mechanisms.

心脏是机体血液循环的动力泵 ,高 +Gz应激对心脏的超微结构、功能和代谢均可造成一定程度的损伤 ,美、法等国也已初步报道了职业飞行员重复高 +Gz作用后对心脏造成的不良影响。然而 ,迄今国内外均未针对重复高 +Gz应激引起的心脏损伤机理进行较系统、深入的研究和采取相应的防护措施。本文综述了急、慢性 +Gz暴露对动物心脏结构和功能造成的损伤效应以及对飞行员心脏造成的不良影响 ,并从应激损伤。

The heart is the dynamic pump of the circulation. To some extent, high +Gz acceleration exposure can result in injuries on cardiac ultrastructure, metabolism and function. Specifically, repeated +Gz exposures can produce harmful effects on aviators, as reported by French and American researchers. However, the mechanisms of injuries on heart under high +Gz stress have not been studied systematically till now; nor have some protective measures been adopted. In this article,acute and chronic +Gz stress induced injuries on cardiac structure and function in animals and detrimental effects on the hearts of pilots are reviewed. Moreover, the related mechanisms are also explained basing on stress injury, oxidative stress and genetic regulation.