定量超声法评价甲亢对骨质量的影响

EVALUATION OF BONE QUALITY IN HYPERTHYROIDISM PATIENTS BY QUANTITATIVE ULTRASOUND METHODS

目的探讨甲亢引发的超声骨质量的变化特征及其临床意义。方法用定量超声法测量 6 4例甲亢患者跟骨的超声振幅衰减和超声传导速度 ,以及骨硬度指数 ,并与性别、年龄相匹配的健康人作对照。同时测量了男、女各 2 0名健康青年人 ,并据此统计分析甲亢组的骨质减少及骨质疏松发生率。结果未经治疗甲亢组的超声振幅衰减和骨硬度指数平均下降 9.5 %和 12 .6 % ,显著低于同龄对照组 (P均 <0 .0 1)。甲亢组骨质丢失发生率达 43.8% ,对照组 7.8% ,有显著性差异 (χ2 =2 5 .7,P <0 .0 1)。结论超声振幅衰减和骨硬度指数可以敏感地检测甲亢引发的骨质量下降。定量超声法操作简单、便携 ,且无放射性污染 ,可能是诊断骨质疏松症的一种有益工具。

ObjectiveTo clarify the features and clinical significance of bone quality changes in hyperthyroidism patients by quantitative ultrasound (QUS).MethodsBroadband ultrasound attenuation (BUA, dB/MHz) , the speed of sound (SOS, s/m) and stiffiness index (STI,%) were respectively measured in 64 untreated hyperthyroidism patients and an age ,sex matched normal control groups. Twenty young and healthy female and male volunteers were detected to establish normal references, incidence of osteopenia and osteoporosis were analyzed acorrdingly.ResultsBUA and STI in hyperthyroidism patients were 9.5 % and 12.6 % lower than those in normal control respectively. Incidence of bone loss in hyperthyroidism patients reached 43.8 % .ConclusionBone loss could be detected with BUA and STI in hyperthyroidism patients. This simple,low cost, portable, and radiation free method may be a useful tools in the diagnosis of osteoporosis.