强迫症的氯丙米嗪与合并暴露疗法比较研究

Combination of Clomipramine with Exposure Therapy in treatment of Obsessive-compulsive Disorder

目的 :探讨暴露疗法对强迫症的疗效 ,并比较暴露疗法对强迫观念及强迫行为疗效的差异。方法 :将符合CCMD -2 -R强迫症诊断标准的 2 8例病人 ,随机将其中的 14例在氯丙咪嗪治疗的基础上联用暴露疗法做为研究组 ,另 14例单用氯丙咪嗪治疗做为对照组 ,均系统治疗 8周 ,用耶鲁 -布朗强迫症量表(Y -BOCS)减分率评定两组治疗强迫症的疗效。结果 :氯丙咪嗪合并暴露疗法组的疗效优于单用氯丙米嗪组 ,尤其是在控制强迫性行为方面更为突出。结论 :氯丙咪嗪合并暴露疗法尤其适用于以强迫行为为主的强迫症病人。

Objective: To compare the effect of combination of clomipramine with exposure therapy with clomipramine alone in treatment of obsessive-compulsive disorder (OCD) Method:A total of 28 patients with OCD according to CCMD-2-R were randomly divided into two groups: clomipramine group and combination group The duration of treatment was 8 weeks for both groups We selected Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) to assess the effect of treatment Results: The combination group had much higher reduction rate in Y-BOCS than clomipramine group, especially for those with compulsive behavior Conclusion: The combination of clomipramine with exposure therapy is more effective than clomipramine alone, especially for compulsive behavior