游泳延缓小鼠衰老的神经内分泌机制

Neuroendocrine mechanisms of the aging retair induced by swimming in mice

探讨适宜游泳应激对D 半乳糖致衰老小鼠抗衰老作用的神经内分泌调节机制。实验分为对照组、适宜应激组、D 半乳糖致衰老组和衰老应激组。检测下丘脑NE、5 HT ,以及血浆ACTH、皮质醇的含量。适宜应激组NE和皮质醇含量明显高于对照组 ,而 5 HT和ACTH含量无明显变化 ,5 HT/NE比值明显减少 ;D 半乳糖衰老组NE和ACTH含量明显低于对照组 ,血浆皮质醇含量降低不明显 ,而 5 HT含量和 5 HT/NE比值明显升高。但是 ,衰老应激组NE、ACTH和皮质醇含量均明显高于衰老组 ,而 5 HT含量和 5 HT/NE比值明显降低 ,并与对照组相近。提示神经内分泌机制可能参与适宜游泳应激对小鼠衰老进程的延缓。

To study the effect of proper swiming stress on the aging mice' neuroendocrine function The mice were divided into 4 groups:the control, the swiming stress (swimming for 15min at 18℃ daily), the aging induced by D galactose (0 12mg/g·d), and the aging plus stress Eight weeks later, the contents of noradrenaline(NE), serotonin(5 HT) in the hypothalamus, adrenocorticotropine(ACTH) and cortisol in blood were measured Compared with the control, the stress group has contents of NE and cortisol increased, 5 HT and ACTH showed no significant changes. The ratio of 5 HT/NE decreased; and in the aging group the content of NE and ACTH significantly decreased, cortisol showed no significant decrease, 5 HT and 5 HT/NE significantly increased In the aging plus stress group the content of NE, ACTH and cortisol were significantly increased while 5 HT and 5 HT/NE were significantly decreased compared with the aging group. It seemed that proper swiming stress might delay aging process by improving the aging mice' neuroendocrine function