涎腺肿瘤患者中p185蛋白和p16蛋白表达及临床意义

The Alterted Expression of p185 and p16 in Patients with Salivary Tumors and Its Clinic Significance

用免疫组化 LSAB法检测维吾尔族患者涎腺恶性肿瘤 1 3例、涎腺多形性腺瘤 1 1例及涎腺非肿瘤组织 1 0例的p1 85蛋白及 p1 6蛋白的表达及变化 ,探讨抑癌基因 p1 6(表达产物为 p1 6蛋白 )、原癌基因 C- erb B- 2 (表达产物为 p1 85蛋白 )在新疆维吾尔族涎腺肿瘤患者中的异常表达与肿瘤病理生物学特征间关系及临床意义 ,为涎腺恶性肿瘤的有效防治提供科学实验依据 ,本研究得出 :(1 )免疫组化法检测 p1 85及 p1 6蛋白的表达 ,可对良、恶性病变从分子水平进行评估 ,并可作为早期诊断及临床治疗涎腺恶性肿瘤的分子生物学指标 ;(2 ) p1 85蛋白的过度表达可能与良性病变的恶性转化有关。

Expression of p185 and p16 in Uygur salivary malignant tumors (13 cases), pleomorphic adenomas (11 casses) and non tumor tissues (10 cases) was detected by immunohistochemistry (LSAB method) to study the alterted expression of p185 and p16 in Uygur patients with salivary tumors related to the biopathology and clinical significance. Conclusion can be reached as follows: 1. Detection of p185 and p16 alteration may offer some molecular index for the early diagnosis, clinical therapy of salivary malignant and benign tumors; 2. p185 overexpression may involve a malignant transformation of benign lesions.