中国维、苗、瑶、壮四个少数民族补体C4的遗传多态现象的检测报告

GENETIC POLYMORPHISM OF THE HUMAN COMPLEMENT COMPONENT C4 IN UIGUR, MIAO, YAO AND ZHUANG NATIONALITIES IN CHINA

使用国际第四届补体遗传学会议推荐的方法及薄层激光扫描技术,检测了我国维吾尔族、苗族、瑶族、壮族的补体组分4(C4)的多态性,并与我们以往检测过的汉族的C4多态性一起进行了比较。结果发现,在C4A座位上,以C4A3频率最高,以下在汉族、苗族、瑶族、壮族中依C4A2、Q0、4、1次序降低。在C4B座位上,频率最高的均为C4B1。其它基因频率的依次排列,汉与维为2、Q0、3,苗与壮为92、Q0、2、3,瑶为Q0、2、92等。民族间的差异比较集中地存在于C4A2、C4B2、C4AQ0、C4BQ0等4个基因。本文还对中国汉族、日本人、白种、黑种人群的C4同种异型差异进行了对比与讨论。

The genetic polymorphism of the fourth complement component (C4) in Uigur, Miao, Yao and Zhuang Nationalities in China was investigated using the methods recommended by thte 4th International Workshop for the Genetics of Complement and the advanced techniques of laser densitometry scanning, and compared with the data of Han Nationality prlviously determined by us. As to C4, the frequency of C4A3 was found as the highest among five nationalities; the remaining frequencies orders were C4A2, Q0, 4, 1 successively among four nationalities except for Uigur. As to C4B, the frequency of C4B1 was found as the highest among five populations; the remaining frequencies orders were C4B2, Q0, 3 in Han and Uigur, 92, Q0, 2, 3 in Miao and Zhuang, Q0, 2, 92 in Yao respectively. The differences among five populations were focused on allotypes of C4A2, C4B2, C4AQ0 and C4BQ0. The differences of C4 genetic frequencies among Chinese Han, Japanese, Caucasian, and Negroid were also discussed.