SLE患者血清sTNF-RⅠ、sTNF-RⅡ和TNF-α的变化

Changes of Serum sTNF-RⅠ, sTNF-RⅡ and TNF-α from Patients with Systemic Lupus Erythematosus

目的 探讨活动期和稳定期系统性红斑狼疮 (SL E)患者血清可溶性肿瘤坏死因子受体 (s TNF- R )、可溶性肿瘤坏死因子受体 (s TNF- R )及肿瘤坏死因子 -α(TNF-α)水平的变化在疾病发生、发展过程中的意义。 方法 应用 EL ISA方法测定 46例 SL E患者及 30例正常人对照血清中 TNF-α和 s TNF- R 、s TNF- R 水平 ,及其与补体 C3 、抗双链 DNA抗体 (ds DNA)、抗核抗体 (ANA)及血沉的相关性。 结果 与对照组相比 ,SL E患者血清中 TNF-α、s TNF- R 和 s TNF- R 都显著升高 ,且活动期升高更为显著 (P<0 .0 1)。活动期患者 s TNF- R 和 s TNF- R 的变化与补体 C3 、ds DNA、ANA及血沉有非常显著的相关性 (P<0 .0 1) ,但与 TNF-α水平无相关性(P>0 .0 5 )。 结论 TNF-α在 SL E的免疫损伤机制中起重要的作用 ,而 s TNF- R 和 s TNF- R 在疾病中具有免疫调控作用 ,并可作为疾病活动的参考指标之一。

Objective\ To investigate the significance of the changes of tumor necrosis factor\|α(TNF\|α) and soluble tumor necrosis factor receptors(sTNF\|RⅠ and sTNF\|RⅡ) in sera from active and inactive systemic lupus erythermatosus(SLE) patients.\ Methods\ 46 patients with SLE were divided into active and inactive groups according to their SLE disease index(SLEDAI) score; sera from these patients and 30 normal controls were tested for TNF\|α and sTNF\|RⅠ and sTNF\|RⅡ.\ The correlation of sTNF\|RⅠ, sTNF\|RⅡ with compliment C\-3, anti\|dsDNA, anti\|neuclear antibody(ANA), ESR and TNF\|α were studied, respectively.\ Results\ Serum levels of TNF\|α, sTNF\|RⅠ and sTNF\|RⅡ in inactive and active SLE patients were in turn significantly increased when compared with normal controls(P<0 01).\ Serum levels of sTNF\|RⅠ and sTNF\|RⅡ in active patients correlated well with the changes of compliment C\-3, anti\|dsDNA, ANA, ESR(P<0 01), but poorly with TNF\|α(P>0 05).\ Conclusion\ TNF\|α plays an important role in the mechanism of immune\|mediated injury, while the role of sTNF\|RⅠ and sTNF\|RⅡ in SLE may be related to immune regulation, and they may act as reliable signs indicating the activity of the disease.\;