环氧酶抑制剂减轻单纯胆囊切除术创伤反应的研究

Study on the effects of cyclo-oxygenase inhibitor on traumatic stress response after chole cyctectomy

目的观察环氧酶抑制剂对胆囊切除术后创伤性应激反应的影响。方法将 6 0例单纯胆囊切除术病人分为实验组 ,从术前 30min始给予意施丁 2 5mg肛塞 ,2次 /d ;对照组按同样方法肛塞面粉胶囊。监测两组病人术后体温、血白细胞 (WBC)、血浆C—反应蛋白 (CRP)水平。结果实验组病人术后 1～ 4天体温显著低于对照组。两组病人术后 1～ 7天血浆CRP水平显著高于术前 ,但实验组显著低于对照组 ,术后 1～ 5天血WBC水平显著高于术前 ,但实验组低于对照组。两组病人的并发症无显著性差异。结论环氧酶抑制剂可以减轻单纯胆囊切除术后机体创伤性应激反应。

Objective To study the effect of cyclo-oxygenase inhibitor (indocontin) on traumatic stress response of patients undergoing cholecystectomy.Method 60 cases of patients with simple cholecystectomy were selected and divided into experiment and control group.Experiment group has indocontin,25 mg/Bid from 1/2 hours before operation to 5 days after operation.conrol group has placebo (wheat powder capsule).Body temperature,plasma c reactive protein (CRP) were monitored.Result body temperature were significantly lower in experiment group than that in control group.A significantly increase was found in CRP level after operation.the increase of plasma CRP level was inhibited significantly in experiment group.The WBC elevated one to five days after operation.which is higher in experiment group than that in control group.Conclusion cyclocygenase inhibitor could alleviate the traumatic stress response after cholecyctectomy.