2Hz和100Hz经皮神经电刺激对大鼠慢性炎症痛治疗作用的比较

Comparison between Therapeutic Effects of Transcutaneous Electrical Nerve Stimulation with the Frequency of 2 Hz and 100 Hz on Chronic Inflammatory Pain in Rats

目的 :观察经皮神经电刺激 (TENS)对大鼠慢性炎症痛的治疗作用。方法 :以完全福氏佐剂造成单发关节炎大鼠慢性炎症痛模型 ,以体重、踝周长、跖屈及背屈关节疼痛试验评分为指标 ,评价多次低频(2Hz)及高频 (10 0Hz)TENS“足三里”穴位对大鼠关节炎的治疗作用。结果 :(1)在体重增长速率方面 ,多次10 0HzTENS明显快于 2HzTENS ;(2 )在缓解关节肿胀方面 ,10 0HzTENS的效果明显优于 2HzTENS ;(3)在缓解疼痛方面 ,10 0HzTENS的作用也明显优于 2HzTENS。结论 :经皮神经电刺激对慢性炎症痛有治疗作用 。

Objective: To observe the effects of repeated transcutaneous nerve stimulation (TENS) with low frequency (2Hz) and high frequency (100Hz) on the chronic inflammatory pain. Methods: The complete Freund′s adjuvant was used to make the monoadjuvant arthritis as a chronic inflammatory pain model. The model animals were divided into 3 groups, the 100Hz TENS group, the 2Hz TENS group and the control group. The percentage increase of body weight, circumference of ankle, score of flexion pain test and score of extension pain test were used to evaluate the therapeutic effect of TENS. Results: (1) Body weight increasing rate in the 100Hz TENS group was markedly higher than that in the 2Hz TENS group and the control group. (2) Circumference of rats′ ankle in the 100Hz TENS group was smaller than that in the 2Hz TENS and the control group. (3) Repeated 100Hz TENS showed more effective on pain relief than that of 2Hz TENS. Conclusion: TENS has therapeutic effects on chronic inflammatory pain in rats, and different frequencies yielded different results.