抗癌药物柔红霉素的光谱电化学研究

Spectroelectrochemistry Studies of Antitumor Antibiotics Daunomycin

采用现场光谱电化学技术 ,结合循环伏安和红外光谱等手段 ,研究了柔红霉素的电极过程 ,并提出了可能的还原机理 .结果表明 ,柔红霉素的还原途径与其浓度存在一定的联系 :稀溶液的还原经历一 ECE过程——得到两个电子还原为柔红霉氢醌后 ,发生化学反应脱去 7位上的糖基侧链 ,得到的 7-去氧柔红霉醌继续被还原 ,生成的自由基中间体可发生歧化反应或通过分子间缔合而稳定 ;当溶液浓度较大时 ,柔红霉素分子在得到一电子生成半醌自由基中间体后 。

The electrode process of antitumor daunomycin has been investigated by using in situ spectroelectrochemical techniques, with the aid of cyclic voltammetry and infrared spectrophotometry. Possible mechanisms of its reduction processes have been discussed where the concentration makes a critical effect. When the DRN concentration is low, two successive one electron reduction steps are demonstrated, which was followed by an aglycon elimination reaction, and then, the product 7 deoxydaunomycinone received one electron to form 7 deoxysemidaunomycione free radical, such radicals can disproportionate or associate easily. But if high, only one electron reduction happened to get the corresponding semiquinone radicals, which can also associate rapidly.