三联疗法治疗原发性肾病综合征35例分析

Analysis on triad therapy(三联疗法) in treatment of 35 patients with primary nephrotic syndrome

目的 :观察糖皮质激素、脑明注射液及黄芪注射液三联疗法治疗原发性肾病综合征的疗效。方法 :将6 8例原发性肾病综合征患者随机分为糖皮质激素对照组 33例和三联疗法治疗组 35例 ,均为每日 1次 ,4周为1个疗程 ,观察疗效及血液流变学指标的变化。结果 :治疗组缓解率 (6 5 .7% )和总有效率 (94.3% )均明显优于对照组 (2 4.2 %和 6 6 .7% ) ,P均 <0 .0 5 ;治疗组复发率 (6 .1% )明显低于对照组 (36 .4% ) ,P<0 .0 5 ;治疗组血液流变学指标的改善明显优于对照组 (P<0 .0 5和 P<0 .0 1)。结论 :三联疗法治疗原发性肾病综合征疗效满意 。

Objective:To observe the curative effects of glucocorticoid,Naoming injection(脑明注射液) and Astragale injection(黄芪注射液)triad therapy on primary nephrotic syndrome.Methods:Sixtyeight cases with primary nephrotic syndrome were randomly divided into control group ( n =33) which treated with glucocorticoid,and treatment group ( n =35) which was treated with triad therapy.Once a day for four weeks as a therapeutic course in both groups.The curative effects and the changes in blood rheology parameters were observed.Results:The remission rate (65 7%) and total effective rate (94 3%) in treatment group were significantly superior to those (24 2% and 66 7% respectively) in control group (all P <0 05).The recurrence rate was significantly inferior (6 1% vs.36 4%, P <0 05) in comparison of the treatment group and the control group.The improvement of blood rheology parameters in treatment group were significantly better than those in control group ( P <0 05 or P <0 01).Conclusions:The curative effects of triad therapy on primary nephrotic syndrome are sufficient.It may decrease obviously recurrence.