阿霉素在常用输液中的稳定性考察

Stability observation of doxorubicin hydrochloride in four infusions

目的:考察阿霉素与 4种常用输液配伍后的稳定性 ,为临床安全用药提供依据。 方法 :采用紫外分光光度法在 2 33nm处测定阿霉素的含量 ,对阿霉素在 4种输液中的溶解速度、热稳定性、光稳定性进行考察。结果 :阿霉素在注射用水中溶解速度最快 ,在 5 0 g/ L 葡萄糖注射液中次之 ,在 5 0 g/ L 葡萄糖氯化钠注射液和 9g/ L 氯化钠注射液中溶解速度较慢 ;阿霉素在输液中的热稳定性较好 ,80℃ 4h内除 9g/ L 氯化钠注射液中的含量降低10 %左右和颜色稍淡外 ,其它输液均无变化 ;室温漫射光对其影响很小 ,10 h内含量、外观、p H值基本无变化 ;但日照对其稳定性影响很大 ,10 min含量即下降 10 %左右 ,溶液颜色也逐渐变淡。结论 :阿霉素可与 4种输液配伍 ,应先用少量注射用水溶解后 ,加入其它 3种输液中混匀静推或静滴 ,操作中应避免阳光直射。

Objective: To investigate the stability of doxorubicin hydrochloride in four infusions. Methods: A UV method was used to determine the content of doxorubicin. The dissolution rate, the heat stability and photosensitivity of doxorubicin in four infusions were observed. Results: The dissolution rate of doxorubicin in sterile water injection was the fastest, that in 50 g/L glucose injection was faster than in 50 g/L glucose and sodium chloride injection and 9 g/L sodium chloride injection. The heat stability of doxorubicin in infusions was good, it had no change except the content of doxorubicin in 9 g/L sodium chloride injection reducing about 10% and the colour of it changing a little in 4h at 80℃. The content, colour and pH had no change under the condition of diffused light in 10 hours. But the content of doxorubicin in infusions reduced about 10% within 10 minutes when exposed to direct sunlight, the colour of them disappeared gradually. Conclusion: Doxorubicin can be used with four infusions avoiding the direct sunlight, but it is better that the drug should be dissolved with sterile water injection and then added it to other three infusions for intravenous injection or intravenous drip.