不同剂量吲哒帕胺对老年高血压降压疗效影响

The influence of Indapamide of several doses on hypotensive effect on hypertension in the elderly

目的 比较小剂量与常规剂量吲哒帕胺对老年高血压的疗效和安全性。方法 选择我院 96例Ⅰ、Ⅱ级老年高血压患者 ,随机分为小剂量 (A组 )和常规剂量 (B组 )组各 48例。A组服吲哒帕胺 1 2 5mg ,B组服 2 5 0mg ,均 1次 d ,疗程为 8周。所有患者均在治疗前、后测血压、血电解质、血糖、血脂及血尿酸并进行比较。结果 A组和B组的降压总有效率分别为 83 3 %和 89 6 % (P >0 0 5 )。两组的血钾、血钙、血糖、胆固醇、甘油三酯、血尿酸治疗前、后均无明显变化 (P >0 0 5 )。结论 小剂量和常规剂量吲哒帕胺治疗老年高血压疗效相近 ,但小剂量治疗更经济、副作用少、更安全。

Objective To compare the effect and safety of low dose and routine dose on hypertension in the elderly.Methods 96 patients were divided randomly into two groups: group A(n=48) treated at a dose of 1 25mg Indapamide and group B(n=48) treated at a dose of 2 5mg Indapamide once daily for 8 weeks.Blood pressure,serum electrolyte,blood glucose,blood lipid,and blood uric acid were measured before and after treatment.Results The effective rate in group A was 83 3%,in group B was 89 6%(P>0 05).There was no significant influence on serum potassium,serum calcium,blood glucose,serum total cholesterol,serum triglyceride,blood uric acid in two groups.Conclusion The effect in two groups was approximate,but group A was economy less side-effect and safety.