冠脉内磁化支架置入术后冠状静脉窦血中NO等物质水平变化

Level changes of serum nitric oxide, oxidized low density lipoprotein, malondialdehyde and superoxide dismutase in coronary sinus after magnetized stent placement

目的 研究冠心病患者冠脉内置入磁化支架后冠状静脉窦血中一氧化氮 (NO)、氧化修饰低密度脂蛋白(ox L DL )、丙二醛 (MDA)及超氧化物歧化酶 (SOD)水平的变化 ,探讨磁化支架防治冠脉再狭窄作用的机制 .方法 经皮腔内冠状动脉成形术及冠脉内支架置入术的冠心病患者 (2 5例 )随机分为磁化支架组 (17例 )及非磁化支架对照组 (8例 ) .经股静脉将右冠状动脉导管置入冠状静脉窦采血 ,采用Griess法等方法测定冠脉内支架置入术中及术后 6 h内冠状静脉窦血中 NO,ox L DL ,MDA及 SOD的水平变化 .结果 磁化支架组术后 6 h冠状静脉窦血中 NO含量较对照组显著升高 (P<0 .0 1) ,而 ox L DL和 MDA与对照组相比降低 (P<0 .0 5 ,P<0 .0 1) ,SOD与对照组相比升高 (P<0 .0 1) .结论 NO升高与磁化支架预防冠脉再狭窄的作用相一致 ,其升高的机制与磁场清除自由基 ,增强抗氧化能力 ,使 ox L DL

AIM To investigate the effects of magnetized stent on the level of serum nitric oxide (NO), plasma oxidized low density lipoprotein (oxLDL), malondialdehyde (MDA) and superoxide dismutase (SOD) in coronary sinus in patients with coronary heart disease after PTCA. METHODS Patients with coronary heart disease randomly received magnetized or unmagnetized stent placement. Placing a right coronary artery catheter into the coronary sinus, we collected blood samples of the patients during the first 6 hours after PTCA and stent placement. Serum levels of NO, oxLDL, MDA and SOD were determined by Griess Method and some other methods. RESULTS Serum levels of NO ( P <0.01) and SOD ( P <0.01) of the magnetized stent patients were significantly higher than those of the controls, while the serum levels of oxLDL ( P <0.05) and MDA ( P <0.01) were markedly lower. CONCLUSION Higher level of NO might be consistent with the Restenosis preventive effect of magnetized stents. Free radical clearance, anti oxidization enhancement, and production of oxLDL reduction by the magnetic field may all play some roles in the step up of serum NO level in this study.