胃食管反流病与反流性咽喉炎的关系探讨

Relations between gastroesophageal reflux disease and reflux laryngitis

目的 :探讨胃食管反流病与反流性咽喉炎发生的关系。方法 :对 130例顽固的慢性咽喉炎患者 ,行胃镜检查或 2 4h食管 pH值监测 ,将检测的胃食管反流病随机分为A、B两组。A组应用抑酸药、促动力药和清热解毒治疗 ;B组 (对照组 )仅用清热解毒的咽喉炎药。对两组咽喉部症状缓解及内镜下病理改善情况进行统计学比较。结果 :检出胃食管反流病 45例(34.6 % ) ,反流性咽喉炎的体征多样化。A组治疗 2 3例 ,有效率 91.3% ;对照组 2 2例 ,有效率 13 .6 % (P <0 .0 1)。结论 :胃食管反流病是导致反流性咽喉炎的重要病因 ,抑酸剂及促动力药可缓解或改善反流性咽喉炎的症状。

Objective:To investigate the relationship between gastroesophageal reflux disease(GRD) and reflux laryngitis.Methods:One hundred and thirty patients with refractory chronic laryngitis were performed gastroscopy and ambulatory 24 hr esophageal pH metry.The patients were divided into two groups.Group A was treated with antacids and motile medications;group B acted as control.Results:Forty five(34.6%) were found gastroesophageal reflux disease in the 130 cases.Of the 23 cases treated in group A,21 (91.3%) healed,and only 3 of the 22 cases(13.6%) in the control healed( P <0.01).Conditions of the reflux laryngitis were of many types.Conclusions:Gastroesophageal reflux disease was major cause for reflux laryngitis,whose symptoms can be relieved by antacids and motile medications.