正常妊娠和妊高征孕妇血浆D-二聚体含量的变化

Changes of plasma D-dimers in normal pregnant women and patients with pregnancy induced hypertension.

目的 观察比较正常妊娠和妊高征妇女血浆D -二聚体 (DD)含量变化。方法 采用ELISA双抗体夹心法 ,检测正常妊娠和妊高征孕妇各 3 0例及非妊娠妇女 2 0例的血浆DD含量变化。结果 正常妊娠和妊高征两组血浆DD含量均高于非孕妇女 (均P <0 0 1) ,妊高征组高于正常妊娠组 (P <0 0 1) ;在妊高征组中轻、中、重度患者血浆DD含量随病情加重逐渐升高并有显著性意义 (P <0 0 1)。结论 正常妊娠孕妇血浆DD水平升高 ,妊高征患者尤为明显 ,动态检测孕妇血浆中DD含量变化 ,对妊高征的早期诊断与防治有重要意义。

Objective To observe and compare the changes of plasma levels of D-dimers(DD) in normal pregnant women and patients with pregnancy induced hypertension(PIH)Methods Plasma levels of DD were measured by means of enzyme-linked immunosordent assays(ELISA).Three groups of women were studied:30 women with PIH,30 nomal pregnant women,and 20 nonpregnant women.Results The plasma DD levels in normal pregnant women and in patients with PIH were higher than that in nonpregnant women(P<0.01).Its level in patients with PIH was higher than that in normal pregnant women(P<0.01).The plasma DD level in patients with PIH gradually grew higher with the development of the illness(P<0.01).Conclusion The plasma DD level in normal pregnant women grows higher and its level in patients with PIH higher even more.To test the plasma DD level continuously has important value in early diagnosis,prevention and treatment of PIH.