早产儿血中胃泌素水平与胃肠道发育研究

Blood gastrin concentration and development of gastrointestinal function in premature infants

目的 探讨早产儿生后血中胃泌素水平的变化及其对胃肠道发育的影响。方法 对 72例早产儿应用放射免疫法监测其生后 12h内开奶前及第 3、7d空腹血中胃泌素的水平 ;并以 16例正常足月新生儿作为对照。结果 ①早产儿组生后开奶前及第 3、7d空腹血中胃泌素水平分别为 (6 1 39± 2 3 6 3)、(93 19± 37 11)、(12 6 33± 45 33)ng/L ,明显低于对照组的 (12 5 88± 30 0 0 )、(135 10± 33 86 )、(178 2 9± 45 93)ng/L(P <0 0 0 1) ;但随胎龄、日龄、奶量增加而升高 ,呈正相关。②早期喂养 (含微量喂养及非营养性吸吮 )能提高早产儿胃泌素水平及其对喂养的耐受性。结论 早产儿消化道机能能适应胃肠道营养 。

Objective\ To study the changes of serum gastrin concentration and its effect to development of gastrointestinal function in premature infants.Methods\ The serum gastrin concentration in 72 premature infants were measured within 12 hour before enteral feeding,on days 3 and 7 of life by using radioimmunoassay 16 full-term neonates were studied as controls.Results\ (1)The serum concentration of gastrin in premature infants before enteral feeding after birth,on days 3 and 7 were 61.39±23.63ng/L,93.19±37.11ng/L,126.33±45.33ng/L respectively,which were significantly lower than those in control group(125.88±30.00ng/L,135.10±33.86ng/L,178.29±45.93ng/L)(P<0.001).But there were positive correlation with gestation age,day age and the volume of mile.(2)Early enteral feeding(include MEN and NNS)could improve the serum gastrin levels and nutritive tolerance in premature infants.Conclusions\ The gastrointestinal functions of prematrue infants are adaptable to enteral nutrition.The rational enteral feeding can promote the gatrointestinal growth and development,and can also promote maturation of gastrointestinal function of premature infants.