非痴呆帕金森病短时记忆障碍的事件相关电位研究

Study of event-related potential about short-term memory disturbance in patients with non-demented Parkinson's disease

目的 评价事件相关电位对非痴呆帕金森病短时记忆障碍诊断的临床价值。方法 对 2 4例非痴呆帕金森病患者 (病例组 )和 30例健康受试者 (对照组 )进行短时记忆测试 ,同时分别完成听觉经典Oddball序列、视觉非经典Oddball序列事件相关电位检查。结果 经典Oddball序列诱发的P30 0潜伏期、波幅与非经典Oddball序列诱发的P45 0潜伏期比较 ,两组间无明显差异 (P >0 .0 5 ) ,病例组P45 0波幅〔( 2 7.0± 3.9) μV〕较对照组〔( 39.7± 6.1) μV〕明显降低 (P <0 .0 5 ) ,且与记忆商值呈正相关 (r =0 .93,P <0 .0 5 )。结论 应用某些特殊诱发模式 ,事件相关电位对短时记忆障碍的诊断有一定的临床价值。

Objective To evaluate the value of event-related potential(ERP) in the diagnosis of short-term memory(STM) disturbance in patients with non-demented Parkinson's disease.Methods 24 patients and 30 controls were examined with test of STM and ERP evoked by classical auditory and non-classical visual Oddball paradigm.Results No difference of latency and amplitude of P300 evoked by classical Oddball model and latency of P450 evoked by non-classical Oddball model was observed among the patients and controls(P>0.05),However,amplitude of P450 in patients was significantly lower than that of controls(P<0.05).There was negative correlation between amplitude and memory quotient(r=0.93,P<0.05).Conclusion ERP evoked by especial paradigm might have centain clinical value in diagnosis of STM disturbance.