输卵管性不孕与抗精子抗体的关系

Relationship between Fallopian Tubal Disease and Anti-sperm Antibodies in Subfertile Women

目的 研究血清抗精子抗体 (As Ab)与输卵管性不孕的关系。方法 采用联免疫吸附技术 (EL ISA)检测2 12 4例不孕妇女血清 As Ab,对 As Ab阳性组和阴性组分别采用一步免疫层析法检测沙眼衣原体 (CT) ,采用聚合酶链反应 (PCR)技术检测解脲支原体 (UU ) ,采用常规妇科检查及阴道涂片检查阴道炎及宫颈炎 ,采用子宫输卵管造影或腹腔镜检查输卵管。结果 As Ab阳性组输卵管病变占 36 .2 % (2 6 1/ 72 1) ,宫颈炎占 41.6 % (30 0 / 72 1) ,明显高于 As Ab阴性组 (5 .49% ,8.5 5 % ) ;输卵管病变组 As Ab阳性率 (77.2 % ,2 6 1/ 338)明显高于正常对照组 (7.6 % ,5 0 / 6 5 6 )。结论 As Ab的产生与上生殖道炎症尤其是输卵管病变有密切的关系 ,因此对不孕症患者应常规检查 As Ab,对妇科检查排除宫颈炎而 As Ab阳性者有必要做子宫输卵管检查 ,发现问题同时对症进行抗炎和免疫治疗。

Objective To explore the relationship between f al lopian tubal disease and antisperm antibodies(AsAb) in subfertile women. Methods Serum antisperm antibodies were measured by an enzyme linked immunosorbent assay (ELISA) from 2124 subfertile women.Results AsAb were detected in 261 of 338 (77.2%) women with tubal disease, and only 50 o f 656 (7.6%) normal women, the positive rate of the former was obviously higher than that of the later. In AsAb positive group, tubal disease comprised 36.2%(26 1/721), cervicitis 41.6%(300/721), which were obviously higher than that in AsAb negative group (5.49%,8.55%).Conclusion It is distinct possibi lity that tubal disease may lead to AsAb production.