尼莫地平和甘露醇对急性脑缺血再灌注大鼠的影响

Protective effect of nimodipine and mannitol on brain injury of cerebral ischemia-reperfusion in rats

目的筛选在急性脑缺血再灌注过程中对脑有较好保护作用的用药方法。方法将 2 4只Wister大鼠制成脑缺血再灌注动物模型 ,随机分为尼莫地平治疗组、甘露醇治疗组和两种药物联合用药组。检测各组超氧化物歧化酶 (SOD)、丙二醛 (MDA)和谷氨酸 (Glu)含量 ,并进行病理学比较。结果尼莫地平和甘露醇联合用药组与其他两组相比 ,有显著性差异。结论尼莫地平与甘露醇联用对急性脑缺血再灌注时的大脑损伤有较好的保护作用。

ObjectiveTo study protective effect of combined medication with nimodipine and mannitol on injury of cerebral ischemia-reperfusion.MethodsA model of cerebral ischemia-reperfusion injury was performed by clipping bilateral common carotid arteries and vagi, then by releasing them to reperfuse blood into ischmic brain of rats. Changes of SOD, MDA and excitatory amino acids( glutamic acid, Glu) in serum were detected after cerebral ischmia-repefusion in different groups. At the same time pathologic study was performed. ResultsTreatment with nimodipine and mannitol is significantly effective than single medication. ConclusionsCombined medication with nimodipine and mannitol protects brain tissue from cerebral ischemia-reperfusion by synergistic action.