高血压患者巨细胞病毒感染与血浆内皮素及P-选择素的关系

Cytomegalovirus infection associated with plasma endothelin and P-selectin in patients with essential hypertension

目的 探讨原发性高血压患者巨细胞病毒 (CMV)感染与血浆内皮素、P 选择素的关系。方法 分别采用化学发光法、放射免疫均相竞争分析法 (RIA)和ELISA法测定 98例原发性高血压患者CMVIgM、IgG及血浆内皮素、P 选择素水平 ,并与 31例健康对照组进行比较。结果 原发性高血压患者CMVIgM阳性率和IgM、IgG双阳性率分别为 5 6 12 %和 5 4 0 8% ,明显高于对照组 (19 35 % ,16 16 % ;P <0 0 5 )。IgG阳性率二组差异无显著性。原发性高血压IgM抗体阳性组血浆内皮素、P 选择素水平分别为 95 5 3ng ml± 5 0 6ng ml、42 5 0ng ml± 3 2 8ng ml,均高于IgM抗体阴性组 (71 6 0ng ml± 4 34ng ml、2 7 41ng ml± 5 2 8ng ml)和对照组 (4 8 77ng ml± 5 96ng ml、19 80ng ml± 4 6 2ng ml) ,结论 活动性CMV感染加重原发性高血压患者内皮损伤 ,诱导内皮素和P

Objective To investigate the relationship between human cytomegalovirus (HCMV) infection and plasma endothelin and P\|selectin in patients with essential hypertension.Methods Blood samples of 98 patients with essential hypertension were collected for HCMV IgM and IgG antibodies,plasma endothelin and plasma P\|selectin by chemiluminescence technique,radio\|immunoassay and ELISA.Results The rates of positive HCMV IgM antibodies and positive rates for both HCMV IgM and IgG antibodies were 56.12% and 54.08%,respectively,which were higher than that of the control group ( P<0.05 ).The level of plasma endothelin and P\|selectin in patients with positive HCMV IgM antibodies was 95.53±5.06 ng/ml and 42.50±3.28 ng/ml,respectively,which were higher than that in patients with negative HCMV IgM antibodies (71.60±4.34 ng/ml and 27.41±5.28 ng/ml) and that of the control group (48.77±5.96 ng/ml and 19.80±4.62 ng/ml).Conclusion These results suggest that HCMV active infection may aggravate vascular endothelium lesion in patients with essential hypertension and contribute to the increase of endothelin and P\|selectin.