复方灯盏花对白斑、扁平苔藓上皮异常增生的影响

The Effect of Herba Erigerontis Compound on Epithelial Dysplasia of Leukoplakia and Lichen Planus

目的 观察复方灯盏花胶囊对白斑、扁平苔藓上皮异常增生的影响。方法 选择患口腔白斑、扁平苔藓的志愿者 45例 ,采用复方灯盏花胶囊治疗 3个月 ,以云芝糖肽、维生素A为阳性对照组 ,作治疗前后临床局部症状、组织病理学变化和增殖细胞核抗原测定值观察对比。结果 复方灯盏花治疗后 ,79.2 %患者上皮异常增生分级有减轻 ,症状改善 ,增殖细胞核抗原阳性细胞率明显降低 ,均优于阳性对照组。结论 复方灯盏花胶囊具有防止白斑和扁平苔藓癌变的作用 ,对细胞动力学的积极影响是其抗癌机制的基础之一。

Objective To explore the effective Chinese medicine to prevent and treat oral precancerous lesions,and study the clinical therapeutic effect of Erigerontis Compound and its celluar dynamic mechanism.Methods Select 45 volunteers suffering from leukoplakia(LK) and lichen planus(LP) who were divided into treatment and control groups.Treatment group (TG) took Herba Erigrontis Compound capsule for 3 months,Control group (CG) received YUN Zhi Polysacchrodepepitide and vitamine A capsule.The results of variation of clinical symptoms,histopathology, and proliferative cell nucleic antigen(PCNA) were observed and compared.Results In 79.2% case the degree of epithelia dysplasia was decreased and the TG was less than that of CG;the positive cell couns of PCNA of TG fewer than that of CG obviously;the symptom of TG lessen.All of these of TG were better than that of CG.Conclusion Herba Erigerontis Compound Capsule can prevent and treat LK and LP confirmly.Its anticanceration mechanism is to affect actively the celluar dynamics.