经关节镜建立颞下颌关节面急性骨软骨缺损动物模型

Establishment of an Animal Model of Osteochondral Defect by Arthroscope in TMJ

目的 经微创手术制备颞下颌关节骨软骨缺损动物模型 ,以减少手术创伤对实验结果的影响。材料 经关节镜对 12只猕猴双侧关节上下腔进行关节面钻孔术 ,造成骨软骨缺损模型 ,对其缺损位置进行定位和记录。结果 12只猕猴 2 4侧关节均在关节镜下进行了关节功能面的骨软骨缺损模型的建立 ,并进行了缺损部位的定位。结论 经关节镜建立猕猴关节面缺损模型是一种仅有微小创伤的方法 。

Objective To create an animal model of osteochondral defect in temporomandibular joint(TMJ) by arthroscope to minimize the surgical injury. Methods Subchondral drilling on the anterior slope of condyle and posterior slope of eminence were performed on 12 rhesus monkeys (24 joints) by arthroscope.Results The osteochondral defect models of TMJ were successfully made on 12 monkeys(24 joints).Conclusion There are fewer injuries and bias in the animal models of TMJ osteochondral defect by arthroscope than by open surgery.