肾上腺髓质素前体N端20肽在不同高血压病中的水平变化

The Mechanism of Proadrenomedullin N Terminal 20 Peptide in Hypertension Patients with EH and RH

目的：观察原发性高血压（ＥＨ）与肾实质性高血压（ＲＨ）患者肾上腺髓质素前体Ｎ端２０肽（ＰＡＭＰ）的水平变化，探讨ＰＡＭＰ的降压机制。方法：用放免法测定ＥＨ与ＲＨ患者的血浆ＰＡＭＰ、去甲肾上腺素（ＮＥ）、肾上腺素（Ｅ）水平并计算它们之间的相关关系。结果：ＥＨ及ＲＨ患者ＰＡＭＰ、ＮＥ、Ｅ均较正常人明显增高，ＰＡＭＰ、平均动脉压（ＭＡＰ）与ＮＥ有明显相关性。结论：ＥＨ及ＲＨ患者ＰＡＭＰ增高可能是机体维持自稳态的一种保护性代偿机制，ＥＨ与ＲＨ代偿程度有所不同。ＰＡＭＰ降压作用与桔抗ＮＥ、Ｅ有关。

Objective: To assess the change of proadrenomedullin N terminal 20 peptide (PAMP) in patients with essential hypertension. Methodes: The plasma concentrations of PAMP, noradrenalin (NE).adrenalin (E) in EH.RH patients were measured by radioimmunoassay (RIA). Result: The plasma concentrations of PAMP .NE..E in patinents with EH.RH were significantly higher than those of normal human, There was a positive correlation between PAMP, the mean arterial pressure (MAP) and NE. E. Conclusion: PAMP is a vasodilator peptide. The change of PAMP may be the compensatory mechanism by which the body maintains homeostasis and there was a difference between the patients with EH and RH.