肺癌组织中CD_(44v6)和nm23的表达及临床意义

EXPRESSION AND CLINICAL VALUE OF CD_(44V6) AND nm23 IN HUMAN CARCINOMA OF LUNG

目的 :探讨 CD4 4v6 和 nm 2 3在肺癌组织中的表达及意义。方法 :应用免疫组织化学方法 ,检测 5 1例肺癌组织中 CD4 4v6 和 nm2 3的表达情况 ,并分析其临床意义。结果 :在 5例类癌和 4例小细胞肺癌 (SCL C)中未见 CD4 4v6 表达。在非小细胞肺癌 (NSCL C)中 ,≤ 6 0岁和 >6 0岁组 CD4 4v6 的阳性率分别为 84 .0 %和 2 9.4 % ,两组间差异有非常显著性 (χ2 =12 .79;P<0 .0 1) ,低分化癌和高中分化癌中 CD4 4v6 的阳性率分别为 87.0 %和 31.6 % ,两组间差异有显著性 (χ2 =13.5 3,P<0 .0 1) ;有和无淋巴结转移组 CD4 4v6 的阳性率分别为 73.3%和 33.3% ,两组间差异有显著性 (χ2 =5 .82 ,P<0 .0 5 ) ;鳞癌和腺癌中 CD4 4v6 的阳性率分别为 85 .7%和 5 0 .0 % ,两组间差异有显著性 (χ2 =5 .0 5 ,P<0 .0 5 ) ;nm2 3在腺癌和鳞癌中的阳性率分别为 6 4 .3%和 14 .3% ,两组间差异有显著性 (χ2 =9.35 ,P<0 .0 1)。结论 :CD4 4v6 可反映 NSCL C的生物学特性 ,是预测其侵袭转移潜能和预后的指标。nm2

Objective:To study the expression and clinical value of CD 44v6 and nm23 in human carcinoma of lung.Methods:The expressions of CD 44v6 and nm23 in tissue samples of 51 carcinoma of lung were detected with the immunohistochemical stain method,and the results were related to clinical data.Results:There was no expression of CD 44v6 in all 5 cases of pulmanary carcinoids and 4 cases of SCLC.Positive rate of CD 44v6 expression in the group of ≤60 year and >60 year of NSCLC was 84.0% and 29.4%, respectively. There was a distinct statistical difference between the two groups(χ 2=12.79, P <0.01).Positive rate of CD 44v6 expression in undifferentiated tumor and in well differentiated ones was 87.0% and 31.6%, respectively.There was a distinct statistical difference between the two groups (χ 2=13.53, P <0.01). Positive rate of CD 44v6 expression in lymphnode positive group and in lymphnode negative one was 73.3% and 33.3% , respectively . There was a distinct statistical difference between the two groups ( χ 2=5.82 , P <0.05) . Positive rate of CD 44v6 expression in human squamous cell carcinoma of lung and adenocarcinoma of lung was 87.5% and 50.0% , respectively.There was a distinct statistical difference between the two groups (χ 2=5.05, P <0.05).Positive rate of nm23 expression in human adenocarcinoma and squamous cell carcinoma of lung was 64.3% and 14.3%,respectively.There was a distinct statistical difference between the two groups (χ 2=9.35, P <0.01).Conclusion:CD 44v6 might be marker in assessing biological behavior,invasion and metastatic potential and prognosis in human carcinoma of lung.It is necessary to cellect more samples for further study in order to confirm prognositc value of expression of nm23 in human carcinoma of lung.