急性脑梗死患者凝血象改变

Changes of coagulation and fibrinolysis in patients with acute cerebral infarction

目的 探讨急性脑梗死患者凝血象变化 ,为预防本病提供依据。 方法 采用ACL 2 0 0型全自动凝血分析仪检测凝血及纤溶有关指标。用血浆纤维蛋白原 (Fg)功能自动化仪检测Fg浓度及其分子的功能 ,用发色底物法检测组织型纤溶酶原激活物 (t PA)、纤溶酶原激活物抑制物 (PAI 1)。 结果 急性脑梗死患者血浆Fg浓度 (3 3 8± 1 3 )g·L-1,其分子功能 4 3 3± 0 5 8,与对照组相比 ,P <0 0 5 ;抗凝血酶Ⅲ (AT Ⅲ )活性 (72 2± 13 2 ) % ,t PA活性 (0 89± 0 16)IU·ml-1、PAI 1活性 (8 2 7± 1 3 4)IU·ml-1,与正常组相比 ,P <0 0 5。 结论 血浆Fg浓度升高及其分子功能增强 ,AT Ⅲ活性降低、t PA活性降低及PAI 1活性增强是急性脑梗死的主要凝血象变化。

Objective To explore the changes of coagulation and fibrinolysis in patients with acute cerebral infarction and to provide evidence to prevent acute cerebral infarction. Methods Coagulations and fibrinolytic activities was tested by ACL 200 coagulation autoanalyzer and plasma Fg Concentration was measured by the automatic method.t PA and PAI 1 were measured by absorbance analytical cycles. Results Plasma concentration and activity of Fg,i.e.(3 38±1 3)g·L -1 ,4 33±0 58,respectively,were significant different from the control group ( P <0 05).Activity of AT Ⅲ was (72 2±13 2)% and t PA was (0 89±0 16)IU·ml -1 while PAI 1 was(8 27±1 34)IU·ml -1 ,which present significant difference from normal group.( P <0 05). Conclusions All these are the main coagulation changes of acute cerebral infarction.Testing coagulation and fibrinolysis is valuble to prevent and treat the disease.