生物健口服液对小鼠免疫功能的影响

Effects of Shengwujian Oral Liquid on Immune Function in Mice

目的 :研究生物健口服液对小鼠体液免疫、细胞免疫、红细胞免疫和单核 -巨噬细胞系统的作用。方法 :用正常小鼠、环磷酰胺 ( CY)致免疫抑制和 2 ,4-二硝基氟苯 ( DN FB)诱导迟发型超敏反应 ( DTH)小鼠模型 ,研究生物健口服液对小鼠 Ig G和补体C3 含量、白细胞总数 ( WBC)、红细胞免疫粘附、DTH作用和碳粒廓清能力等实验指标的影响。结果 :生物健口服液能提高正常和免疫抑制小鼠 Ig G和补体 C3 含量 ( P <0 .0 5～ 0 .0 1) ;提高低白模型小鼠 WBC数量 ( P <0 .0 1) ;增强红细胞免疫粘附能力 (P <0 .0 1) ;增强碳粒廓清能力 ( P <0 .0 1)和 DNF B诱导 DTH( P <0 .0 1)。结论 :生物健口服液能增强小鼠 (尤其是免疫抑制状态下 )体液、细胞免疫功能和非特异性的红细胞免疫粘附能力、碳粒廓清能力 ,故具有生物反应调节剂作用。

Objective:To investigate effects of Shengwujian Oral Liquid on humoral immunity, cellular immunity, red blood cell (RBC) immunity and macrophage-phagocyte system (MPS).Methods:To observe the effects of Shengwujian Oral Liquid on serum IgG and complement C 3 content, white blood cell (WBC) count, RBC immune adhering function, 2,4-dinitrofluorobenzene (DNFB) induced-delayed type hypersensitivity (DTH) and phagocytic ability of macrophage in either normal mice or cyclophosphamide (CY)-induced-immunosuppressed mice.Results:Serum IgG and complement C 3 contents were increased in normal and/or CY-induced-immunosuppressed mice (P<0.05～0.01); CY-induced-leucopenia was improved (P<0.01); RBC immune adhering function was enhanced (P<0.01); phagocytosis of macrophage was elevated (P<0.01); DNFB induced-DTH was potentiated (P<0.01).Conclusions:Shengwujian Oral Liquid possesses a similar ability of a biological response modifier as levamisole.