吸入利多卡因治疗哮喘急性发作的临床研究

Clinical study of nebulized lidocaine inhalation in the treatment of acute asthma.

目的 探讨激素抵抗型和激素敏感型哮喘急性发作时 ,雾化吸入利多卡因的临床疗效。方法 采用随机、双盲、对照的方法 ,进行了前瞻性研究。哮喘急性发作患者 ,分为A、B两组 :A组 (18例 )为激素抵抗型哮喘 ;B组 (18例 )为激素敏感型。随机各自分为A1 、A2 和B1 、B2 组 ,每组 9例。在常规治疗的基础上 ,A2 和B1 组雾化吸入利多卡因 ,作为实验组 ;A1 和B2 组则雾化吸入生理盐水 ,作为对照组。结果 试验组与对照组在心率、呼吸频率、呼气流速峰值 (PEF)、第一秒用力呼气量 (FEV1 )等方面 ,差异有显著性意义 (P <0 0 5 )。A2 与B1 的各项监测指标 ,无明显差异 ;A1 与B2 的差异较大 ,但其数据的比较 ,均无统计学意义 (P >0 0 5 )。结论 哮喘急性发作时 ,加用利多卡因雾化吸入治疗 ,临床疗效良好 ,尤其是激素抵抗型哮喘。

Objective To evalute the effect of nebulized lidocaine inhalation in asthma during an acute attack.Methods A randomized,double blind,placebo controlled and prospective study was conducted.36 cases were divided into 4 groups (A 1,A 2,B 1 and B 2) with 9 cases in each group.A 1 and A 2 were the patients with steriod resistant asthma(SRA);B 1 and B 2 were steroid sensitive asthma(SSA).Being maintained on routine treatment,A 2 and B 1 were also treated with nebulized lidocaine.While A 1 and B 2 were assigned to receive nebulized normal saline inhalation as placebo controlled groups.Results There were significant differences between experimental groups and placebo controlled groups in heart rate,respiratory rate,peak flow rate,and forced expiratory volume in one second.In placebo controlled groups,A 1 was worse than B 2,but not significantly differant.Conclusion It was beneficial for the patient with asthma during acute attack to be treated with nebulized lidocaine,especially those patients suffering from steroid resistant asthma. [