大黄酸与山楂总黄酮的药效学研究

Pharmacodynamic effects of rhein and total flavonoids from hawthorn

目的 研究大黄酸与山楂总黄酮对大鼠尿液生成量的影响。方法 实验分 4组 ,分别为正常对照 (生理盐水 )组、大黄酸组、山楂总黄酮组和阳性对照 (呋塞米 )组 ,采用大鼠膀胱插管法收集尿液 ,观察给药前后各组尿量的变化情况。结果 给药 4h后 ,大黄酸组和山楂总黄酮组总尿量分别为 (4.9± 1.0 8)ml和 (4.45± 0 .6 0 )ml,与正常对照组 4h后总尿量 (6 .4± 1.2 5 )ml比较差异显著 (P <0 .0 1)。

Objective To study the effects of rhein and total flavonoids from hawthorn in urine volume of rat.Methods The rats were divided into four groups, including control(physiologic saline)group,rhein group, total flavonoids group and furosemide group, the urine volumes of rat was collected and observed.Results The total urine volume was (4.9±1.08)ml and (4.45±0.60)ml in four hours after administration of rhein and total flavonoids respectively. The urine volume was reduced significantly compare with the control(6.4ml± 1.25 ml).Conclusion It suggests that rhein and total flavonoids from hawthorn may inhibit the production of urine in rat.