罗库溴铵以限时法和预注法行快速气管插管的比较

Comparison of the timing principle and the priming principle of rocuronium for rapid intubation

目的 比较罗库溴铵以限时法和预注法行快速气管插管的条件、肌松效应及对循环系统的影响。方法 限时 (Ⅰ、Ⅱ )组诱导前 30秒静注 0 6mg/kg罗库溴铵 ,诱导后 4 5秒 (Ⅰ )、6 0秒(Ⅱ )行气管内插管 ;预注 (Ⅲ )组诱导前 2分钟预注 0 0 6mg/kg罗库溴铵 (诱导量 0 5 4mg/kg) ,诱导后 6 0秒行气管内插管。记录拇内收肌诱发颤搐反应的抑制和恢复过程 ,评价各组插管效果。结果气管内插管条件各组间无明显差异 ;气管内插管时T1抑制百分比Ⅲ组明显小于其他各组 ;各组对循环系统的影响都很小。

Objective To study endotracheal intubating condition, neuromuscular block and cardiovascular effects of rocuronium for rapid intubation using the timing principle and the priming principle.Methods Patients in group Ⅰ and Ⅱ received rocuronium 0 6mg/kg 30s before the administration of thiopental 5mg/kg.Patients in group Ⅲ received rocuronium 0 06mg/kg 2min before the administration of thiopental and rocuronium 0 54mg/kg.Intubation was accomplished 45s after induction in group Ⅰ and 60s after induction in other groups.The course of depression and recovery of twitch response of the adductor pollicis muscle were recorded and intubating conditions were assessed according to a grading scale.Results Intubating conditions were not significantly different among the three groups.Twith depression of T 1 at the time of intubation in group Ⅲ is significantly smaller than that in the others.The cardiovascular effect in all groups were minimal.Conclusion The timing principle of rocuronium for rapid intubation is better than the priming principle. [