硒对大骨节病病区人体红细胞免疫功能的影响

Effect of selenium on the red cell immune function of human in Kashin-Beck disease area

目的 探讨硒及含硒的谷胱甘肽过氧化物酶 (GPX)对大骨节病 (KBD)病区人体红细胞免疫功能的影响。方法 测定KBD病区人体血硒含量 ,GPX活性 ,红细胞C36R花环率和IC花环率及血清RCIA促进率和抑制率 ,以及补硒对上述指标的影响。结果 ①病区人体血硒含量、GPX活性和红细胞G3bR花环率明显低于非病区 ;血清RCIA抑制率明显高于非病区 ;②病区人体IC花环率 ,血清RCIA促进率与非病区人体无明显差异 ;③补硒 1 2周后 ,血硒含量 ,GPX活性 ,C3bR花环率明显提高 ;血清RCIA抑制率明显降低。④病区人体普遍处于低硒状态 ,且红细胞免疫功能均低下。结论 KBD病区人体红细胞免疫功能低下和血清RCIA抑制因子增高是低硒所致的一种普遍效应 ,而不是KBD病区人体所特有。

Objective To investigate the effect of selenium (Se) and glutathione peroxidase (GPX) on the red cell immune function of people in Kashin-Beck disease area. Methods This research mainly measured the blood Se content,GPX activity, the rosette formation rates of erythrocyte C 3b R and immune complexes, promote and restrain rates of serum red cell immune adherence (RCIA) and the effects of Se supplementation. Results ①Blood Se content, GPX activity and rosette formation rate of erythrocyte C 3b R of human in endemic area were significantly reduced but the restrain rate of serum RCIA was remarkably higher than those of human in non-endemic area;②The rosette formation rate of immune complexes and the promote rate of serum RCIA were not difference between the human in endemic area and non-endemic area;③Blood Se content, GPX activity,rosette formation rate of erythrocyte C 3b R were increased apparently but the restrain rate of serum RCIA was reduced apparently after supplyment Se for 12 weeks;④Se level and red cell immune function of human in endemic area were lower.Conclusion The red cell immune function reduction and serum RCIA restrain factor increase of human in Kashin-Beck disease area induced by low Se is general response and non-special.