大肠杆菌耐热性肠毒素(ST)的分子生物学研究进展

Research progress in molecular biology on the heat-stable enterotoxin of Escherichia coli

大肠杆菌的耐热性肠毒素 (ST)在产肠毒素性大肠杆菌引起的腹泻中扮演重要的角色 ,对人类和家畜的健康构成很大的威胁 .文章从ST的理化特性、致病机理等一般生物学特性到基因克隆、定点突变以及分子结构与功能的关系等分子生物学特征 ,全面概述了ST的分子生物学研究进展 ,对于从分子水平全面了解ST的结构、性质、致病机理以及免疫原性等生物学性状具有重要意义 .

It is the heat stable enterotoxin of Escherichia coli that plays an important role in the diarrhea caused by enterotoxigenic E.coli ,the health of human beings and domestic animals is under great threat of it.This article summarizes all round research progress in molecular biology on ST,including the aspects of physical and chemical characteristics,pathogenic mechanism,gene cloning,gene mutation,as well as the relationship between its molecular structure and function.It means much for grasping the significance comprehensively of ST,with its biological nature,such as structure,characteristics,pathogenic mechanism as well as immunogenicity.