卵巢上皮癌血清、腹腔积液中血管内皮因子测定及其意义

THE SIGNIFICANCE OF SERUM AND ASCITE VEGF LEVELS IN OVARIAN CYSTOADENOCARCINOMA

目的 :探讨血清中血管内皮因子 (VEGF)水平在卵巢上皮癌中的诊断价值。方法 :以 2 2例卵巢上皮良性肿瘤 ,10例卵巢交界性上皮肿瘤及 47例卵巢上皮细胞癌为研究对象 ,2 0例健康妇女为对照组 ,用 EL ISA法测定各组术前血清及部分腹腔积液中 VEGF水平。结果 :卵巢上皮癌中 ,FIGO分期 、 期患者血清 VEGF水平明显高于 、 期患者 (P<0 .0 5 ) ;病理分化差的患者血清 VEGF水平高于分化好的患者 (P<0 .0 1) ;有明显腹腔积液的患者血清 VEGF水平高于腹腔积液不明显患者 (P<0 .0 1)。结论 :血清 VEGF水平与卵巢上皮癌的恶性生物学行为有关 。

Objective:To evaluate the clinical significance of serum and ascite VEGF in ovarian cystoadenocarcinoma.Methods:22 patients with benign ovarian tumor,10 patients with borderline ovarian tumor and 47 patients with ovary cystoadenocarcinoma were included as three study groups,while 20 healthy women were selected as controls.The serum and ascite VEGF were analyzed by Enzyme Linked immunosorbent assary.Results:Compared to benign and borderline tumors,the serum VEGF levels were significantly higher in ovary cystoadenocarcinoma,with the highest values in stage Ⅲ-Ⅳ ( P <0.05) and in architectural grade 3 neoplasms ( P <0.01).Conclusion:Serum VEGF levels seemed to be correlated with the maligmant behavior of ovarian cystoadenocarcinoma,which might be an interesting prognostic indicator in ovarian cystoadenocarcinoma.