疟史与疟原虫血症关系的研究(英文)

EFFECT OF MALARIA-LIKE HISTORY AS A RISK FACTOR ON PARASITAEMIA OF HEALTHY PEOPLE AND FEBRILE PATIENTS IN BANLAO TOWNSHIP, CANGYUAN COUNTY, YUNNAN, CHINA

目的 研究疟史对健康人和发热病人原虫血症的作用。 方法 1989年 5月和 10月在中国云南省沧源县班老乡作了两次横断面调查。专业人员在对健康人采血、涂片、镜检的同时 ,进行问卷调查 ,调查内容包括疟史、性别、居住地海拔及村名 5个方面。在 4月和 10月期间收集发热病人的情况 ,用 EPI INFO 6 .0和 STATA 5 .0软件对数据进行处理。 结果 单因素分析发现疟史和年龄是无症状带虫者 [ML H比值比为 3.98(95 %可信限为 2 .48～ 6 .40 ) ,年龄 2 1～ 40的比值比为 0 .19(95 %可信限为 0 .0 9～0 .39) ,年龄≥ 40的比值比为 0 .38(95 %可信限为 0 .16～ 0 .90 ) ]的危险因素。多因素分析发现年龄是混杂因素 ,冲淡了疟史的作用 ;而疟史是原虫血症发热病人的保护因素 [比值比为 0 .37(95 %可信限为 0 .2 1～ 0 .6 5 ) ]。 结论 有疟史者很有可能是无症状的带虫者 ,是传播疟疾的传染源 ,应在早期阶段就对其重新治疗。

Objective To study the effect of malaria like history as a risk factor on asymptomatic parasitaemia of healthy people and on symptomatic parasitaemia of febrile patients. Method Two cross sectional studies were made in May and October of 1989 in Banlao Township, Cangyuan County, Yunnan, China. Blood sample slides were collected, stained and examined by professional staff, and information on malaria like history, sex, age, elevation and village name were collected by interview using questionnaire while taking slides. Data on febrile patients were collected in April to October, 1989. Data were analyzed using Epi Info 6.0 and Stata 5.0. Results Malaria like history (MLH) and age were the risk factors for asymptomatic parasitaemia of healthy people, with OR being 3.98 (95% CI 2.48-6.40) for MLH, and 0.19 (95% CI 0.09 -0.39) for age 21-40 and 0.38 (95% CI 0.16-0.90) for age of ≥40. Age confounded and diluted the effect of MLH. MLH has effect on symptomatic parasitaemia of febrile patients, with OR being 0.37(95% CI 0.21-0.65). Conclusion These healthy people with MLH are more likely to be malaria parasite carriers and act as infection source of malaria transmission. Effort should be made to retreat those people in early transmission stage. Those healthy people with MLH are less likely to be re infected.