血管活性物质测定在心血管疾病中的意义

Significance of Vasoactive Substances Levels Determination in Patient with Angiocardiopathy

目的 :检测原发性高血压 (EH)和冠心病 (CHD)患者血中CNP、NO、CGRP、ET的含量 ,探讨其与内皮细胞功能的关系及临床意义。方法 :EH组 30例、CHD组 33例、正常对照组 30例 ,均为男性。CNP、CGRP、ET采用放射免疫分析法测定 ,NO采用生化比色镉还原法测定。结果 :EH和CHD组分别与对照组比较CNP、ET含量明显增高 (CNP :P <0 .0 1,ET :P <0 .0 5 ) ,NO、CGRP则明显降低 (P <0 .0 1) ;相关分析表明 :两组患者CNP与CGRP之间具有显著负相关性 (EH组r=0 .5 6 7,P <0 .0 1、CHD组r =0 .42 8,P <0 .0 5 )。结论 :检测EH和CHD血中CNP、NO、CGRP、ET含量变化 ,为研究EH ,CHD与内皮细胞功能关系、发病机理等提供了有价值的实验室依据。

Objective The serum contents of CNP?NO?CGRP and ET in patients with essential hypertension (EH) and coronary heart disease (CHD) were measured to study the relationship between those substances levels and the function of endothelial cell and its clinical significance. Method Blood speciman were from 30 patients with EH? 33 with CHD and 30 controls (all male). CNP?CGRP and ET were determined by RIA, NO was determined by biochemical cadmium reduction method. Results Compares with those in controls, the contents of CNP and ET increased significantly ( P <0.01, P <0.05, respectively), while the contents of NO?CGRP decreased ( P <0.01) significantly in EH and CHD Patients, correlation analysis indicated: CNP levels were significantly negatively correlated to CGRP levels in patiens with EH and CHD (EH r =0.567, P <0.01, CHD r =0.428, P <0.05).Conclusion Detection of changes of CNP?NO?CGRP and ET contents in blood of patients with EH and CHD provides a valuable laboratory basis for study of its relationship with endothelial cell function and the pathogenesis of dysfunction.