线性DNA复制后5′端空缺的填补
The 5′-end Gap Repair after Linear DNA Replication
摘要
介绍了近年来线性DNA复制后 5′端空缺填补问题的研究进展及其在控制细胞的衰老、癌变等方面的重要作用 .对 5′端空缺填补的问题 ,认为不论何种填补方式 ,DNA都是通过特殊的末端顺序 ,在 3′端形成模板引物结构而完成空缺的填补 .
The progress in the Studies of how to repair 5′-end gap after linear DNA replication in recent years are introduced. This mechanism plays and important role in control ling cell aging and carcinogenesis.
出处
《宁波大学学报（理工版）》
CAS
2001年第4期88-91,共4页
Journal of Ningbo University：Natural Science and Engineering Edition
参考文献9
-
1White L K, Wright W E, Shay J W. Telomerase inhibitors[J]. Trend Biotech, 2001,19(3):114～120.
-
2Counter C M, Hirte H W, Bacchetti S, et al. Telomerase activity in human ovarian carcinoma[J]. Proc Natl, Acad Sci, USA, 1994,91(8):2 900～2 904.
-
3Kornberg A. DNA Replication, 2nd ed[J]. WH Freeman company, 1991.403～410.
-
4Van Steensel B, Smogorzewska A, De lang T. TRF2 protects human telomeres from end-to-end fusions[J]. Cell, 1998,92(3):401～413.
-
5Ray A, Rung K W. The C-terminus of the major yeast telomere binding-proting Raplp enhances telomere formation[J]. Mol Cell Biol, 1998,18(3):1 284～1 295.
-
6Shore D. Telomeres-unsticky ends[J]. Science, 1998,281:1 818～1 819.
-
7Nakamura T M, Cech T R. Reversing time:origin of telomerase[J]. Cell, 1998,93(5):587～590.
-
8Green E C, Bednenko J, Shippen D E. Flexible positioning of the telom ase-associated nuclease leads to preferential elimination of nontelomeric DNA[J]. Mol Cell Biol, 1998,18(3):1 552～1 554.
-
9Shore D. Telomeric chromatin:replicating and wrapping up chromosome end[J]. Curr Opinion Genet Der, 2001,11(2):189～198.
