绝经后生殖系统恶性肿瘤患者骨代谢的变化

Changes of bone metabolism in postmenopausal patients with malignant genital tumor

目的 探讨绝经后生殖系统恶性肿瘤患者骨代谢的变化。方法 分别采用放射免疫法、Behr’s法及ACP酶学测定法检测了 32例自然绝经患者 (绝经组 )和 32例自然绝经后发生女性生殖系统恶性肿瘤患者 (肿瘤组 )血清雌二醇 (E2 )、骨性碱性磷酸酶 (bonealkalinephosphatase ,BALP)和抗酒石酸酸性磷酸酶 (tartrateresistentacidphosphatase ,TRAP)浓度。 结果 绝经组与肿瘤组血清E2 浓度无显著差异 (P >0 0 5 )。肿瘤组血清BALP显著低于绝经组 (P <0 0 5 )。绝经组与肿瘤组血清TRAP无显著差异 (P >0 0 5 )。

Objective To investigate the changes of bone metabolism in postmenopausal women with malignant genital tumor.Methods Thirty-two postmenopausal women (postmenopause group)and thirty-two postmenopausal women with malignant tumor (tumor group)were studied.The serum estradiol(E 2),bone alkaline phosphatase(BALP)and tartrate-resistent acid phosphatase (TRAP)levels were detected by RIA,Behr's and ACP method,respectively.Results There was no significant difference of the serum E 2 level between postmenopause and tumor group(P>0 05).The serum BALP level in tumor group was lower than that in the postmenopause group(P<0 05)and no significant difference of the serum TRAP level was seen between postmenopause and tumor group(P>0.05).Conclusion The changes of bone metabolism in postmenopausal patients with malignant tumor are more serious than those of without.