一氧化氮在胎儿-胎盘功能监测中的作用

Effects of Nitric Oxide on Monitoring Placental Function

目的研究足月妊娠妇女血清一氧化氮(NO)含量与胎盘功能的关系。方法采用Griess方法测定30例胎盘功能不全足月初孕妇外周血中NO的稳定代谢产物亚硝酸基/硝酸基的含量,以30例胎盘功能正常的孕妇作对照,同时测定胎盘重量和新生儿体重。结果⑴实验组和对照组血清NO含量分别为76.86±29.67μmol/L和1190.16±25.93μmol/L,两组比较有极显著性差异(P<0.01);⑵实验组与对照组的胎盘重量及新生儿体重分别为473.3±31.4g、533.3±37.9g和3094.5±175.6g、3336.7±251.9g,两组比较有极显著性差异(P<0.01),且胎盘重量及新生儿体重与NO含量呈明显正相关。结论足月妊娠妇女NO含量与含量与胎盘功能密切相关,与胎血盘、胎儿发育呈正相关。

Objective To find out the relationship between nitric oxide(NO)concentration and placental function in term pregnant women.Methods We measured serum NO 2 /NO 3 concentrations?placental weight and birth weight in30term pregnant wom-en of placental insufficiency and30term pregnant women of normal placental functiion.Results⑴Significantly lower NO concentrations were found in study group compared with control group;⑵The placental weight and the birth weight were marked-ly lighter in study group than those of control group.There was a positive correlation between the NO concentrations and placental weight or birth weight.Conclusion NO concentration may play a role as placental function regulators.This suggests an important role of NO in the regulation of fetal and placental development.