特异性CTL治疗慢性乙肝

The effects of the specific cytotoxic T lymphocyte therapy on chronic hepatitis B

目的寻找打破慢性乙肝免疫耐受的有效方法,诱发机体免疫应答,提高抗病毒效果,探讨特异性CTL对慢性乙肝的治疗作用。方法将35例慢性乙肝随机分为两组,治疗组在一般保肝药物基础上加用特异性CTL,每周1次,6次为1个疗程。结果治疗组HBeAg和HBV-DNA阴转率分别为44.4%和50.0%,对照组的阴转率分别为11.7%和11.7%。两组比较差异有显著性(P<0.05)。结论CTL疗法抗HBV作用较为明显,无毒副作用,并具有一些独特之处,为治疗慢性乙肝提供了新的方法。

Subject In order to find out the effec-tive method to reduce the immune tolerance against hepatitis virus B,induce the specific immune re-sponse and improve anti-virus effect,explore the ef-fects of the specific cytotoxic T Lymphocyte on treating chronic hepatitis B in patients.Methods Thirty-five patients with chronic hepatitis B were randomly divided into experimental group and con-trol group.The patients in experimental group re-ceived both the conventional drugs and the specific cytotoxic T lymphocyte therapy once a week andup to six times.Results The rates of HBeAg and HBV -DNA from positive to negative were44.4%and50.0%in experimental group,but they were11.7%and11.7%in control group.There was significant difference between two groups(P<0.05).Conclusion The specific cytotoxic T lym-phocyte therapy is valuable in treating chronic hepatiis B and with little side effects.It can be a new specific therapy for chronic hepatitis B.