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高同型半胱氨酸血症致动脉粥样硬化机制 被引量：1

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摘要 同型半胱氨酸是引起动脉粥样硬化及其他血管性疾病的危险因素 ,其机制可能是通过增加机体氧化应激因子的细胞毒性作用 。
作者 蔡东联 陈小莉
机构地区 第二军医大学附属长海医院营养科中国人民解放军临床营养中心
出处 《国外医学（卫生学分册）》 2001年第5期295-298,共4页 Foreign Medical Sciences(Section of Hygiene)
关键词 同型半胱氨酸 动脉粥样硬化 发病机理
分类号 R363 [医药卫生—病理学]
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参考文献15

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同被引文献17

  • 1Xue J,Dong Q,Han X,et al. Effects of HELP therapy on acute ischemic stroke and vascular endothelial cell function. The A- pher Dial,2007,11(3) : 171-176.
  • 2Matthew T, David-Oxide AM. Nitrous nesthesia on plasma homo- cysteine and endothelial function. Anesthesiology, 2008,109 (4) : 657-663.
  • 3Nasir K, Tsai M, Rosen BD, et al. Elevated homocysteine is asso- ciated with reduced regional left ventficular function: the Multi- Ethnic Study of Atheresclerosis. Circulation, 2007,115 (2) : 180-187.
  • 4Chen CL,Huang RF,Chen YH,et al. Folate deficiency-induced oxidative stress and apoptosis are mediated via homocysteine-de- pendent over production of hydrogen peroxide and enchanced ac- tivation of NF-kB in human HepG2 cells. Biomed Pharmacother, 2001,55 : 434-442.
  • 5Bar RS,Peacock ML, Spanheimer RG,et al. Differential binding of insulin to human arterial and venous endothelial cells in pri- mary culture. Diabetes, 1950,29:991-995.
  • 6Marian J,Muisa B,Michiel L,et al. High cumulative insulin ex- posure: a risk factor of at hemsclemsis in type 1 diabetes. Athemsclerosis, 2005,181 : 185-192.
  • 7Duncan E, Ezzat V, Keamey M. Insulin and endothelial function: physiological environment defines effect on atherosclerotic risk. Curr Diabetes Rev, 2006,2 ( 1 ) : 51-61.
  • 8Dandona P, Chaudhuri A, Mohanty P, et al. Anti-inflammatory ef- fects of insulin. Curr Opin Clin Nutr Metab Care,2007,10(4) : 511- 517.
  • 9Hoogeveen EK, Kostense PJ,Jakobs C, et al. Hyperhomocysteine- mia increase risk of death,especially in type 2 diabetes:5 year follow up of the Hoom Study. Circulation,2000,101 : 1506-1511.
  • 10Fonseca VA,Fink LM,Kern PA. Insulin sensitivity and plasma homocysteine concentrations in non 2 diabetic obese and normal weight subjects. Atherosclerosis, 2003,167 : 105-109.

引证文献1

二级引证文献8

国外医学（卫生学分册）
2001年 第5期

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