胎儿纤维结合素在早产诊断及预测中的价值

The Value of Fetal Fibronectin in Diagnosis and Prediction of Preterm Delivery

胎儿纤维结合素是细胞外基质中一种由种植的滋养层组织分泌的糖蛋白 ,含有称为“癌胚区”的抗原决定簇 ,可被单克隆抗体 FDC- 6识别。孕 2 0～ 37周宫颈阴道分泌物中的胎儿纤维结合素可能是一个对早产有良好诊断、预测价值的标记物。尤其是其阴性预测值高 ,有助于避免不必要的医学干扰。

Fetal fibronectin is a glycoprotein found in the extracellular matrix,which is secreted by implanting trophoblastic tissue.It contains an epitope called the oncofetal domain,which is recognized by the monoclonal antibody FDC 6.Fetal fibronectin detected in cervicovaginal secretions between 20 and 37 weeks gestation seems to be a marker for preterm delivery with a good value of diagnosis and prediction.Especially,the high negative predictive value of fetal fibronectin sampling supports avoiding unnecessary medical intervention.