平均红细胞体积和红细胞计数筛查妊娠合并轻型地中海贫血的价值

Mean Corpuscular Volume and Red Blood Cell in the Screening of Thalassaemia Trait in Pregnant Women

目的 :探讨平均红细胞体积 (MCV)、红细胞计数 (RBC)检测在筛查妊娠合并轻型地中海贫血中的价值。方法 :90 9例孕妇在常规产前检查时 ,同时检查外周血 RBC、MCV、血红蛋白浓度、平均红细胞血红蛋白含量 (MCH)、平均红细胞血红蛋白浓度 (MCHC)及血红蛋白电泳等指标 ,根据检测结果分为地中海贫血组 31例、非地中海贫血组 16 2例、正常对照组 716例。结果 :平均红细胞体积在正常对照组最高 ,非地贫组降低 ,地贫组最低 (P<0 .0 1) ;红细胞计数在地贫组明显高于非地贫组甚至高于正常对照组 (P<0 .0 1) ;RBC/ MCV比值在地贫组明显高于非地贫组及正常对照组 (P<0 .0 1) ,正常对照组与非地贫组之间无显著性差异。结论 :地中海贫血患者有明显的 MCV与 RBC分离现象 ,平均红细胞体积降低和红细胞计数升高为其特征性改变 ,临床上检测 MCV、RBC及 RBC/ MCV比值有助筛查轻型地中海贫血。

Objectives:To evaluate the value of combined measurement of mean corpuscular volume(MCV)and red blood cell (RBC)in the screening of thalassaemia trait in pregnant women.Methods:909 pregnant women at prenatal exvisit were agreed undergo screening which consist of hemoglobin (HGB),RBC,MCV,mean corpuscular hemoglobin(MCH),mean corpuscular hemoglobin concentration (MCHC),hemoglobin electrophoresis.The results in different groups were analyzed.Results:There were 716 cases in normal group,162 cases in non thalassaemia group and 31 cases in thalassaemia group.The MCV was significant lower in thalassaemia group,and RBC was significant high.RBC/MCV ratio was significant higher than normal group and non thalassaemia group.Conclusions:Low MCV and High RBC were the characteristic changes of thalassaemia trait in pregnancy.We recommend the use of MCV,RBC and RBC/MCV ratio in the screening of thalassaemia trait in pregnant women.