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NIS基因转染肿瘤细胞介导^(131)I治疗

Transfection of the Na^+/I^- symporter gene into tumors for radioiodide therapy
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摘要 钠 /碘同向转运体 (NIS)是一种跨膜糖蛋白 ,具有主动运输碘的能力。NIS的异常与许多甲状腺疾病有关。将 NIS基因转染到肿瘤细胞使其表达 NIS并摄取 1 3 1　 I已获成功 ,但 1 3 1　 I在细胞或病灶内停留的时间很短 ,达不到治疗剂量 ,故延长 1 3 1　 I的有效半衰期和提高 Na +/I - symporter is a membrane glycoprotein that catalyzes the active accumulation of I -. The abnormality of NIS gene will lead to thyroid disease. We had succeeded in transfecting the Na +/I - symporter into tumors for radioiodide concentration. However, the effective half life is too short to acquire therapeutic dose. So we should research into prolonging the effective half life and increased effective transfection.
作者 黄蕤
机构地区 四川大学华西医院核医学科
出处 《国外医学（放射医学核医学分册）》 2001年第5期204-209,共6页 Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
基金 国家自然科学基金资助项目 ( 30 170 2 81)
关键词 钠 碘同向转运体 基因转染 放射性碘 治疗 肿瘤 Na +/I - symporter gene transfection radioiodide therapy
分类号 R817 [医药卫生—影像医学与核医学]
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  • 1Sphitzweg C,Joba W,Eisenmenger W, et al. Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complementary DNA from salivary gland, mammary gland, and gstfic mucosa [J ]. J Clin Endocrinol Metab, 1998, 83: 1746-1751.
  • 2Dai G, Levy O, Carrasco N. Cloning and characterization of the thyroid iodide transporter[J] ,Nature, 1996,379:458-460.
  • 3Smanik PA, Ryu KY, Karl S, et al. Expression, Exon-Intron Organization, and Chromosome Mapping of the Human Sodium Iodide Symporter[J]. Endocrinology, 1997, 138:3555-3558.
  • 4Levy O, Antonio D L, Christopher S, et al. N-linked glycosylation of the thyroid Na+/I symporter (NIS)[J]. J Biol Chem, 1998, 273: 22657-22663.
  • 5Eskandari S, Donald DF, Dai G, et al. Thyroid Na+/I- symporter [J]. J Biol Chem, 1997, 272: 27230-27238.
  • 6Kogai T, Endo T, Saito T, et al. Regulation by thyroid-stimulating hormone of Sodium/Iodide symporter gene expression and protein levels in FRTL-5 cells[J].Endocrinology, 1997,138: 2227-2232.
  • 7Koichi S, Atsumi M, Saito J, et al. Follicular thyroglobulin suppresses iodide uptake by suppressing expression of the Sodium/Iodide symporter gene[J]. Endocrinology, 1999, 140:5422-5430.
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国外医学（放射医学核医学分册）
2001年 第5期

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