血清CEA、CA199、CA125、CA153联检对肺癌的诊断价值

Diagnostic Significance of Measuring CEA、CA199、CA125 and CA153 For Patients With Lung Cancer

目的 :评价血清CEA、CA199、CA12 5、CA15 3水平对肺癌诊断的临床价值。方法 :测定 6 0例肺癌患者血清CEA、CA199、CA12 5、CA15 3水平 ,并观察其在不同TNM分期的变化及其不同病理水平变化。结果 :肺癌组CEA、CA199、CA12 5、CA15 3水平明显高于正常对照组和良性肺病组 ,4项肿瘤标志扬水平以腺癌最高 ,鳞癌次之 ;联合检测可提高肺癌诊断率。TNM临床分期越晚 ,CEA、CA199、CA12 5、CA15 3水平越高。结论 :该 4项肿瘤标志物在肺癌的诊断、病情监测方面可为临床提供有价值的资料。

Objective: To evaluate the value of measurement of 4 tumor markers (CEA, CA199, CA125, CA153) for diagnosis in patients with lung cancer. Methods: These tumor markers in serum were measured in 60 patients with lung cancers, and change of the markers were observed in these patients with different stage and pathohistological evidence. Results: The serum levels of the markers in patients with lung cancer were significantly higher than normal cortrol and benign lung disease. The serum levels of the markers were the highest in adenscarcinoma, squamous carcinoma took second place. Combination of these tumor markers increased sensitivity and accuracy of measurement. The later the stage of TNM of lung cancer, the higher levels of 4 tumor markers would be revealed. Conclusions: Measurement of CEA, CA199, CA125 and CA153 in serum provide useful information for diagnosis and evaluation of disease extent in patients with lung cancer.