丙戊酸钠治疗癫痫的临床应用

Clinical Analysis of Sodium Valproate in Treating Epilepsy-65 Cases Report

目的 :观察缓释剂型丙戊酸钠治疗癫痫 6 5例的效果。方法 :儿童按 2 0～ 30mg·kg-1·d-1,成人按 5 0 0～ 10 0 0mg·d-1口服丙戊酸钠。结果 :丙戊酸钠治疗 5 6例癫痫有效率 (86 .2 % ) ,其中显效 47例占 72 .3% ,有效 7例占 10 .7% ,效差 2例占 3.1% ,无效 9例占 13.8%。大多数患者的有效血浓度为 5 0～ 10 0 μg·ml-1。结论 :丙戊酸钠对神经外科各种类型癫痫有较好疗效 ,但应根据其临床发作类型、药物反应及丙戊酸钠血浓度调整应用。

Objective: To investigate the efficiency of sodium valproate(VPA) in treating epilepsy in 65 cases. Methods: The oral dose of VPA in treating children was 20～30mg·kg -1 ·d -1 . By the same way,the dose in adult was 500～1000mg·d -1 . Results: The general clinical efficacy of VPA was 86.2% in treating all types of epilepsy.In these 56 cases,47 cases (72.3%) were cured perfectly,7 cases (10.7%) were cured effectively,2 cases (3.1%) were treated poorly,and 7 cases (10.7%) were failed.The effective blood level of VPA is 50～100μg·ml -1 . in most patients. Conclusion: VPA is an effective drug in treating all kinds of epilepsy in our neurosurgery department.For the good clinical result,it is important to adjust the dose of VPA according to the epilepsy type,drug reaction and the blood level.