血药法测定扑热息痛片的动力学参数和生物利用度

Blood Madicine Method To Test Paracetamol's Dynamics Parameter And Percent Of Organisms Utilization

目的:掌握血药法测定片剂动力学参数及生物利用度的操作技术。方法:健康家兔喂服单剂量500mg/3kg 扑热息痛片,采用紫外分光尢度法测定血药浓度,并描绘药一时曲线,求算有关动力学参数及生物利用度。结果:AUC=49μg/ml·h;t_m=2.5h;C_m=10.12μg/ml;k=0.4595;t_(1/2)=1.508h。结论:扑热息痛体内过程符合一室模型血管外给药。

Purpose:Master the operate technology that blood madicine to test paracetamol's dynamics parameter and percent of organisms utilization.Method:let healthy rabbit eat single calculate 500mg/3kg paracetamol,use ultraviolet ray testing density of blood madicine, drawing madicine—time curve,calculate danamics parameter and percent of organisms utilization. Result:AUC=49μg/ml.h;t_m=2.5h;C_m=10.12μg/ml;k=0.4595;t_(1/2)=1.508h.Conclusion: Paracetamol dissolving in body can meet giving medicine out of one ventricle of heart's blood ves- sel.