直肠癌根治术后髂内动脉加门静脉置泵化疗预防局部复发和肝转移的研究

Internal iliac artery and portal vein chemotherapy in prevention of local recurrence and hepatic metastasis after radical resection of rectal carcinoma

目的 探讨髂内动脉加门静脉置泵化疗预防直肠癌术后局部复发和肝转移的价值。方法 将我院 96例直肠癌术前随机分成两组 ,门静脉加髂内动脉灌注化疗组 (治疗组 ) 4 8例与外周静脉化疗组 (对照组 ) 4 8例 ,对其疗效进行分析。结果 治疗组 1、3、5年生存率分别是 10 0 %、83 %、5 2 % ;局部复发率和肝转移率是 13 %、13 %。对照组是 88%、68%、3 2 % ,2 6%、2 8%。两组各项指标分别比较 ,差异有显著意义 (P <0 0 1)。结论 置泵灌注化疗在预防直肠癌术后局部复发和肝脏转移的治疗效果优于外周静脉全身化疗。

Objective To evaluate the effect of internal iliac artery and portal vein chemotherapy in preventing local recurrence and hepatic metastasis after radical operation of rectal carcinoma. Methods 96 patients in PLA 309 Hospital with rectal carcinoma undergoing radical resection were divided into 2 groups: Portal vein and iliac artery perfusion chemotherapy group (pump chemotherapy group, 48 cases) and peripheral venous chemotherapy control group (48 cases). Results In the pump chemotherapy group, the 1 , 3 , and 5 year survival rates, local recurrence rate and hepatic metastasis rate were respectively 100%?83%?52%?13%? and 13%, compared with 88%?68%?32%?26% and 28% in control group (all P<0 01). Conclusions Pump implementation chemotherapy is superior to peripheral venous chemotherapy in preventing postoperative local recurrence and hepatic metastasis in patients with rectal carcinoma.